MiR-3168 (p = 1.98 × 10− 8 ), miR-4718 (p = 4.24 × 10− 5 ), and miR-6125 (p = 6.60 × 10− 5 ) were the most differentially expressed miRNAs and were further quantified in 43, 48, and 53 patients, respectively. The baseline expression of miR-3168 (p = 0.0456, OR = 1.03, 95% CI 1.001.06) and miR-4718 (p = 0.0388, OR = 1.56, 95% CI 1.03 2.46) were associated with an increased risk of nephrotoxicity, whereas miR-6125 showed a trend (p = 0.0618, OR = 1.73, 95% CI 0.983.29). MiR-4718 showed the highest AUC (0.77, 95% CI 0.610.93) with sensitivity of 66.76 and specificity of 79.49.
CONCLUSIONS:
We have provided evidence of baseline plasmatic expression of miR-3168, miR-6125, and miR-4718 as potential predictors of cisplatin-induced nephrotoxicity.