In view of the importance of the nine-banded
armadillo (Dasypus novemcinctus) in
leprosy research, we studied the
ultrastructure of the normal
epidermis of this species. The three basic
cell types of
human epidermis were identified in
armadillo skin keratinocytes,
melanocytes, and Langerhans'
cells. The
role of Langerhans'
cells in the
human cell-mediated
immune system and the description of changes in the number and structure of Langerhans'
cells in
human leprosy make detailed observations of these
cells in the
armadillo highly relevant. Clear
cells with ultrastructural features typical of Langerhans'
cells were observed in normal
armadillo epidermis in all areas of
skin sampled (
abdomen,
chin,
ear, and
thigh), but are fewer than in
human skin. These baseline findings are valuable for further studies on Langerhans'
cells and the
cell-mediated immune function in
armadillos with naturally acquired or experimental
leprosy.