Cortisone and DDS were used together in the treatment of reactions occurring in about a dozen cases of kleprosy of the tuberculoid type. Seven severe cases were followed and reported. Two of these were changed to potassiumantimony tartrate injections, and one was given that drug for a recurrence of the condition. The other four patients did not require additional treatment for the reaction. In all but one case the edema and erythema could be controlled, but twelve weeks of treatment and an average total dose of four grams of cortisone were required. In addition to the improvement of the skin lesions, there was a slight reduction in the numbers of bacilli. None of the patients developed an exacerbation of neuritis while on DDS and cortisone. There were no untoward reactions, but the relatively high cost of the treatment requires emphasis.