Use of genetic profiling in leprosy to discriminate clinical forms of the disease
Bleharski, Joshua R; Li, Huiying; Meinken, Christoph; Graeber, Thomas G; Ochoa, Maria-Teresa; Yamamura, Masahiro; Burdick, Anne; Sarno, Euzenir N; Wagner, Manfred; Röllinghoff, Martin; Rea, Thomas H; Colonna, Marco; Stenger, Steffen; Bloom, Barry R; Eisenberg, David; Modlin, Robert L.
s.l; s.n; Sep. 2003. 4 p. graf.
No convencional
en Inglés
| SES-SP, HANSEN, Hanseníase, SESSP-ILSLACERVO, SES-SP | ID: biblio-1240972
Leprosy presents as a clinical and immunological spectrum of disease. With the use of gene expression profiling, we observed that a distinction in gene expression correlates with and accurately classifies the clinical form of the disease. Genes belonging to the leukocyte immunoglobulin-like receptor (LIR) family were significantly up-regulated in lesions of lepromatous patients suffering from the disseminated form of the infection. In functional studies, LIR-7 suppressed innate host defense mechanisms by shifting monocyte production from interleukin-12 toward interleukin-10 and by blocking antimicrobial activity triggered by Toll-like receptors. Gene expression profiles may be useful in defining clinical forms of disease and providing insights into the regulation of immune responses to pathogens.
Biblioteca responsable:
BR191.1
Ubicación: [{"text": "BR191.1", "_a": "09142/s"}, {"text": "BR191.1", "_a": "09145/s"}]
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