Impact of comorbidities in mexican SARS-COV-2-positive patients: a retrospective analysis in a national cohort
Kammar-García, Ashuin; Vidal-Mayo, José de J.; Vera-Zertuche, Juan M.; Lazcano-Hernández, Martín; Vera-López, Obdulia; Segura-Badilla, Orietta; Aguilar-Alonso, Patricia; Navarro-Cruz, Addi R..
Rev. invest. clín
; 72(3): 151-158, May.-Jun. 2020. tab, graf
Artículo
en Inglés
| LILACS | ID: biblio-1251849
ABSTRACT
Background:
The coronavirus disease 2019 outbreak is a significant challenge for health-care systems around the world.Objective:
The objective of the study was to assess the impact of comorbidities on the case fatality rate (CFR) and the development of adverse events in patients positive for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in the Mexican population. Materials andmethods:
We analyzed the data from 13,842 laboratory-confirmed SARS-CoV-2 patients in Mexico between January 1, 2020, and April 25, 2020. We investigated the risk of death and the development of adverse events (hospitalization, pneumonia, orotracheal intubation, and intensive care unit [ICU] admission), comparing the number of comorbidities of each patient.Results:
The patient mean age was 46.6 ± 15.6 years, 42.3% (n = 5853) of the cases were women, 38.8% of patients were hospitalized, 4.4% were intubated, 29.6% developed pneumonia, and 4.4% had critical illness. The CFR was 9.4%. The risk of hospitalization (odds ratio [OR] = 3.1, 95% confidence interval [CI] 2.7-3.7), pneumonia (OR = 3.02, 95% CI 2.6-3.5), ICU admission (OR = 2, 95% CI 1.5-2.7), and CFR (hazard ratio = 3.5, 95% CI 2.9-4.2) was higher in patients with three or more comorbidities than in patients with 1, 2, or with no comorbidities.Conclusions:
The number of comorbidities may be a determining factor in the clinical course and its outcomes in SARS-CoV-2-positive patients.Asunto(s)
Humanos Masculino Femenino Embarazo Adolescente Adulto Persona de Mediana Edad Anciano Anciano de 80 o más Años Adulto Joven Neumonía Viral/epidemiología Infecciones por Coronavirus/epidemiología Pandemias Betacoronavirus Complicaciones Infecciosas del Embarazo/epidemiología Respiración Artificial/estadística & datos numéricos Asma/epidemiología Enfermedades Cardiovasculares/epidemiología Fumar/epidemiología Comorbilidad Modelos de Riesgos Proporcionales Estudios Retrospectivos Huésped Inmunocomprometido Enfermedad Crítica Cuidados Críticos/estadística & datos numéricos Enfermedad Pulmonar Obstructiva Crónica/epidemiología Diabetes Mellitus/epidemiología Insuficiencia Renal Crónica/epidemiología SARS-CoV-2 COVID-19 Hospitalización/estadística & datos numéricos México/epidemiología Obesidad/epidemiología
Biblioteca responsable:
BR1.1
powered by iAHx-2.18-89
Biblioteca Virtual en Salud