An economic evaluation of the controlled temperature chain approach for vaccine logistics: evidence from a study conducted during a meningitis A vaccine campaign in Togo
a recent innovation in support of the final segment of the immunizationsupply chain is licensing certain vaccines for use in a controlled temperature chain (CTC), which allows excursions into ambient temperatures up to 40°C for a specific number of days immediately prior to administration. However, limited evidence exists on CTC economics to inform investments for labeling other eligible vaccines for CTC use. Using data collected during a MenAfriVac⢠campaign in Togo, we estimated economic costs for vaccinelogistics when using the CTC approach compared to full cold chainlogistics (CCL) approach.
Methods:
we conducted the study in Togo's Central Region, where two districts were using the CTC approach and two relied on a fullCCL approach during the MenAfriVac⢠campaign. Data to estimate vaccinelogisticscosts were obtained from primary data collected using costing questionnaires and from financial cost data from campaign microplans. Costs are presented in 2014 US dollars.
Results:
average logisticscosts per dose were estimated at $0.026±0.032 for facilities using a CTC and $0.029±0.054 for facilities using the fullCCL approach, but the two estimates were not statistically different. However, if the facilities without refrigerators had not used a CTC but had received daily deliveries of vaccines, the average cost per dose would have increased to $0.063 (range $0.007 to $0.33), with larger logisticscost increases occurring for facilities that were far from the district.
Conclusion:
using the CTC approach can reduce logisticscosts for remote facilities without cold chaininfrastructure, which is where CTC is designed to reduce logistical challenges of vaccine distribution