ABSTRACT Background The International
Cholesterol Management Practice Study is a multinational collaborative effort to describe the
effectiveness of the
lipid-lowering
therapy (LLT) as well as the main barriers to achieve the
low-density lipoprotein cholesterol (LDL-C)
goals Objective The objective of the study was to investigate factors associated with the
achievement of LDL-C
goals in
Mexico using real-
life data
Methods This was a cross-sectional
observational study from 18
physicians across different
health facilities in
Mexico,
who provided information about their practices between August 2015 and August 2016. We included
patients treated for ≥3 months with any LLT in whom LDL-C measurement on stable LLT was available for the previous 12 months Results We included 623
patients with a mean age of 59.3 ± 12.7 years; 55.6% were
women. The mean LDL-C value on LLT was 141.8 ± 56.1 mg/dL. At enrollment, 97.4% of
patients were receiving
statin therapy (11.3% on high-intensity
treatment). Only 24.8% of the very-high cardiovascular (CV)
risk patients versus 26.4% of the high
risk and 52.4% of the moderate
risk patients achieved their LDL-C
goals. Independent factors associated with non-
achievement of LDL-C
goal were
statin intolerance,
overweight and
obesity, abdominal obesity,
female sex, high CV
risk, use of
public health-care service,
metabolic syndrome,
type 2 diabetes, and
hypertriglyceridemia. Higher-
level of education was associated with a lower
risk of not achieving LDL-C
goals Conclusions
Achievement of LDL-C
goals is suboptimal in
Mexico, especially in
patients with the highest CV
risk. The main barriers to achieve the
goal are easily detectable. Implementation of LLT should be adapted to the
patients
needs and profile.