Brain Tumor Heterogeneity
Belsuzarri, Telmo Augusto Barba; Neves, Maick Willen Fernandes; Costa, Otávio Augusto da; Soares, Diego Alves; Melo Filho, Fernando Antônio de; Guimarães, Mariana Mazzuia; Gonçales, Tiago Fernandes; Zeviani, Wolnei Marques; Araújo, João Flávio Mattos.
Arq. bras. neurocir
; 40(3): 253-256, 15/09/2021.
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en Inglés
| LILACS | ID: biblio-1362147
Tumor heterogeneity is the concept that different tumor cells provide distinct biomorphological lesions, gene expressions, proliferation, microenvironment and graduated capacity of metastatic lesions. Brain tumor heterogeneity has been recently discussed about the interesting interaction of chronic inflammation, microenvironment, epigenetics and glioma steam cells. Brain tumors remain a challenge with regards to medication and disease, due to the lack of treatment options and unsatisfactory results. These results might be the result of the brain tumor heterogeneity and its multiple resistance mechanisms to chemo and radiotherapy.
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