Chronic inflammatory diseases, subclinical atherosclerosis, and cardiovascular diseases: Design, objectives, and baseline characteristics of a prospective case-cohort study ‒ ELSA-Brasil
Bensenor, Isabela M.; Goulart, Alessandra C.; Pereira, Alexandre C.; Brunoni, André R.; Alencar, Airlane; Santos, Raul D.; Bittencourt, Márcio S.; Telles, Rosa W.; Machado, Luciana Andrade Carneiro; Barreto, Sandhi Maria; de Almeida-Pititto, Bianca; Janovsky, Carolina Porto Silva; Sgarbi, José Augusto; Tebar, William R.; Meneghini, Vandrize; Barbosa Junior, Fernando; Ribeiro, Ana Cristina de Medeiros; Pasoto, Sandra Gofinet; Pereira, Rosa Maria R.; Bonfá, Eloísa; Sipahi, Aytan M.; Santos, Itamar de S.; Lotufo, Paulo A..
Clinics
; 77: 100013, 2022. tab, graf
Artículo
en Inglés
|
LILACS-Express
| ID: biblio-1375197
Abstract Objectives This analysis describes the protocol of a study with a case-cohort to design to prospectively evaluate the incidence of subclinical atherosclerosis and Cardiovascular Disease (CVD) in Chronic Inflammatory Disease (CID) participants compared to non-diseased ones. Methods A high-risk group for CID was defined based on data collected in all visits on self-reported medical diagnosis, use of medicines, and levels of high-sensitivity C-Reactive Protein >10 mg/L. The comparison group is the Aleatory Cohort Sample (ACS) a group with 10% of participants selected at baseline who represent the entire cohort. In both groups, specific biomarkers for DIC, markers of subclinical atherosclerosis, and CVD morbimortality will be tested using weighted Cox. Results The high-risk group (n = 2,949; aged 53.6 ± 9.2; 65.5% women) and the ACS (n=1543; 52.2±8.8; 54.1% women) were identified. Beyond being older and mostly women, participants in the high-risk group present low average income (29.1% vs. 24.8%, p < 0.0001), higher BMI (Kg/m2) (28.1 vs. 26.9, p < 0.0001), higher waist circumference (cm) (93.3 vs. 91, p < 0.0001), higher frequencies of hypertension (40.2% vs. 34.5%, p < 0.0001), diabetes (20.7% vs. 17%, p = 0.003) depression (5.8% vs. 3.9%, p = 0.007) and higher levels of GlycA a new inflammatory marker (p < 0.0001) compared to the ACS. Conclusions The high-risk group selected mostly women, older, lower-income/education, higher BMI, waist circumference, and of hypertension, diabetes, depression, and higher levels of GlycA when compared to the ACS. The strategy chosen to define the high-risk group seems adequate given that multiple sociodemographic and clinical characteristics are compatible with CID.
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