ABSTRACT Objective Investigate
pulse wave velocity and central systolic
blood pressure among pediatric
population with
chronic kidney disease.
Methods In this
cross-sectional study, 57
patients (61.4%
male)
aged 6.2 to 17.5 years old, 44 with nondialysis
chronic kidney disease and 13 on chronic
dialysis, were included in the
analysis. The
pulse wave velocity and the central systolic
blood pressure were measured with an oscillometric
device with an inbuilt
ARC SolverⓇ
algorithm and were compared with previously established percentiles. Results The
prevalence of elevated
pulse wave velocity was 21.1% (95%Cl 11.4-33.9) and elevated central systolic
blood pressure was 28.1% (95%CI 17.0-41.5). According to the generalized
linear model, there was a higher
risk of elevated
pulse wave velocity in
patients undergoing chronic
dialysis treatment than nondialysis
chronic kidney disease patients (adjPR=4.24, 95%CI 1.97-9.13, p=<0.001). Hypertensive
patients (stage 2) had a higher
risk of elevated
pulse wave velocity than normotensive ones (adjPR=2.70, 95%CI 1.05-6.95, p=0.040), as did
patients younger than 12 years than the older
patients (adjPR=2.95, 95%CI 1.05-8.40, p=0.041). Hypertensive
patients had a higher
risk of elevated central systolic
blood pressure than normotensives (adjPR=3.29, 95%Cl 1.36-7.94), as did
patients undergoing chronic
dialysis treatment when comparing to nondialysis
chronic kidney disease patients (adjPR=2.08, 95%Cl 1.07-4.02). Conclusion Younger age,
dialysis, and
hypertension in
children are independently associated with higher
pulse wave velocity.
Hypertension and
dialysis are independently associated with higher central systolic
blood pressure.