Reducing infection risk in multiple sclerosis and neuromyelitis optica spectrum disorders: a Brazilian reference center's approach / Redução do risco de infeção em esclerose múltipla e doença do espectro neuromielite óptica: abordagem de um centro de referência brasileiro
Gomes, Ana Beatriz Ayroza Galvão Ribeiro; Feo, Lucas Bueno; Silva, Guilherme Diogo; Disserol, Caio César Diniz; Paolilo, Renata Barbosa; Lara, Amanda Nazareth; Tonácio, Adriana Coracini; Mendes, Maria Fernanda; Pereira, Samira Luísa Apóstolos; Callegaro, Dagoberto.
Arq. neuropsiquiatr
; 80(10): 1057-1066, Oct. 2022. tab
Artículo
en Inglés
|
LILACS-Express
| ID: biblio-1420222
Abstract Background Multiple sclerosis (MS) and neuromyelitis optica spectrum disorders (NMOSD) are the most common autoimmune diseases of the central nervous system (CNS). They present chronic relapsing courses that demand treatment with disease-modifying drugs (DMDs) to prevent inflammatory activity. Disease-modifying drugs lead to immunomodulation or immunosuppression through diverse mechanisms (e.g., shifting lymphocyte and cytokine profile, suppressing specific lymphocyte subpopulations). Thus, patients are more prone to infectious complications and associated worsening of disease. Objective To present feasible strategies for mitigating the infection risk of MS and NMOSD treated patients. Methods Targeted literature review concerning the management of infection risk with an emphasis on vaccination, therapy-specific measures, and particularities of the Brazilian endemic infectious diseases' scenario. Conclusion We propose a vaccination schedule, infectious screening routine, and prophylactic measures based on the current scientific evidence. Awareness of emergent tropical diseases is necessary due to evidence of demyelinating events and possible parainfectious cases of MS and NMOSD.
Biblioteca responsable:
BR1.1
Texto completo
Documentos relacionados