Abstract Objective The aim is to evaluate the diagnostic value of
Activin A levels in
serum and pleural fluid on Parapneumonic
Pleural Effusion (PPE).
Methods The authors collected
serum and pleural fluid from 86 PPE and 37 Non-PPE (NPPE)
patients. Including
Activin A, levels of
biomarkers such as
Lactate Dehydrogenase (LDH),
Procalcitonin (PCT), and
C-Reactive Protein (CRP) were measured. All factors were calculated for
association with days after admission. The diagnostic potential of
biomarkers on PPE was considered by
Receiver Operating Characteristic (ROC) curve
analysis. Results Levels of
Activin A in
serum and pleural fluid of PPE
patients were significantly higher than those of the NPPE
patients. Moreover, concentrations of
Activin A in pleural fluid showed a more obvious relevant days after admission.
ROC curve analysis found that
Activin A in pleural fluid had AUCs of 0.899 with 93%
sensitivity and 84%
specificity for PPE
diagnosis. Conclusion
Activin A in pleural fluid correlated with
disease severity could act to
diagnose PPE.