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Did COVID-19 lockdown delay actually worsen melanoma prognosis?

Gil-Pallares, Pedro; Figueroa-Silva, Olalla; Gil-Pallares, Maria Eugenia; Vázquez-Bueno, José Ángel; Pineyro-Molina, Francisca; Monteagudo, Benigno; Heras-Sotos, Cristina De las.
An. bras. dermatol ; 98(2): 176-180, March.-Apr. 2023. tab, graf
Artículo en Inglés | LILACS-Express | ID: biblio-1429657
Abstract

Background:

The COVID-19 lockdown possibly meant a delay in the diagnosis and treatment of melanoma and therefore, worsening its prognosis. This unique situation of diagnosis deferral is an exceptional opportunity to investigate melanoma biology.

Objectives:

To evaluate the immediate and mid-term impact of diagnosis delay on melanoma.

Methods:

A retrospective observational study of melanoma diagnosed between March 14th 2019 and March 13th 2021. We compared the characteristics of melanomas diagnosed during the first 6-month period after the lockdown instauration and a second period after recovery of normal activity with the same periods of the previous year, respectively.

Results:

A total of 119 melanomas were diagnosed. There were no differences in age, sex, incidence, location, presence of ulceration or mitoses, and in situ/invasive melanoma rate (p > 0.05). After the recovery of the normal activity, Breslow thickness increased in comparison with the previous year (2.4 vs 1.9 mm, p < 0.05) resulting in a significant upstaging according to the AJCC 8th ed. (p < 0.05). Study

limitations:

The main limitation is that this is a single-center study.

Conclusions:

The COVID-19 lockdown implied a diagnosis delay leading to a mid-term increase in Breslow thickness and an upstaging of invasive melanomas. However, the detection deferral did not result in a higher progression of in situ to invasive melanoma, in our sample.
Biblioteca responsable: BR1.1