In vitro susceptibility of the Sporothrix brasiliensis to aqueous extracts of the green tea (Camellia sinensis L. Kuntze) / Suscetibilidade in vitro de Sporothrix brasiliensis à atividade inibitória de extratos aquosos de chá-verde(Camellia sinensis L. Kuntze)
Waller, Stefanie Bressan; Madrid, Isabel Martins; Serra, Emanoele Figueiredo; Gomes, Angelita dos Reis; Cleff, Marlete Brum; Faria, Renata Osório de.
Acta Vet. Brasilica
; 9(4): 342-347, 2015. tab, map
Artículo
en Inglés
| VETINDEX | ID: biblio-1453595
Sporotrichosis is a zoonosis caused by fungi of the Sporothrix schenckii complex, whichSporothrix brasiliensis is prevalent in cats and dogs in Brazil. Itraconazole is the antifungal used for treatment,but the emergence of resistance has encouraged the search for therapeutic alternatives in medicinal plants.Among the benefits properties of green tea (Camellia sinensis L. Kuntze), it is included the antifungal activity,but there are no data that prove its potential in sporotrichosis. Aimed to evaluate the in vitro antifungal activityof green tea against Sporothrix brasiliensis. Infusion and decoction of dried leaves were prepared at 10% andtested through broth microdilution test (CLSI M38-A2), that was also performed with itraconazole. Nine clinicalisolates of S. brasiliensis from cats and dogs in South Brazil and one standard strain of S. schenckii were tested.The results were expressed in minimal inhibitory concentration (MIC) and minimal fungicidal concentration(MFC). All isolates were inhibited by infusion and decoction (MIC90 of 3.125 mg mL-1for both extracts),without statistic difference, but the fungicidal activity was weak or no occurred (MFC90 > 50 mg mL-1for both).In itraconazole, S. brasiliensis were sensitive at MIC50 of 2 μg mL-1and S. schenckii to MIC of 0.0625 μg mL-1,but the antifungal resistance was observed (MIC90 and MFC50/90 > 16 μg mL-1). For the first time, the satisfactoryinhibitory activity of the infusion and decoction of green tea make its promising in the treatment ofsporotrichosis. However, more studies are needed for its use
Biblioteca responsable:
BR68.1
Ubicación: BR68.1
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