Background:
A great variety of
natural products have been evaluated for the
skin wound healing due to anti-inflammatory,
antioxidant and antibacterial activities, and
procollagen synthesis, of which may be mentioned the
honey and
propolis. Inturn,
low-level laser therapy (
LLLT) is considered an important tool in the
treatment of
skin wounds, because of
ability toraise the
ATP production, to stimulate the
microcirculation, and formation of new
blood vessels. Therefore, this study aimedto assess the influence of
LLLT, alone or combined with
natural products, in the healing of excisional
skin wounds in
rats.Materials,
Methods &
Results:
One hundred twenty-six
male Wistar rats,
aged 14 weeks, were randomly divided intoseven groups (n = 18 per group) according to
wound treatments G1 (negative control)
0.9% saline solution; G2 (positive control)
allantoin +
zinc oxide ointment; G3
LLLT; G4 mixture of
honey + 5%
propolis hydroalcoholic solution;G5
LLLT + mixture of
honey +
hydroalcoholic solution of 5%
propolis; G6
LLLT +
honey in natura; G7
LLLT + 5%
propolis hydroalcoholic solution. Six
rats from each group were euthanized on the 7th, 14th, and 21th postoperative days.Macroscopic and histological evaluations of
wound healing were performed. A decrease in
wound area occurred in allgroups, but in general G4 had the higher reduction and G1 and G3 had the lower reductions. These findings correspondedto the percentage of
wound contraction, since the largest contraction was G4 and the lowest contractions were G1 andG3. Histological
analysis showed no significant difference among groups...