Efeito do extrato aquoso de própolis marrom sobre a produção de IFN- Após imunização contra parvovírus canino (CPV) e coronavírus canino (CCoV) / Effect of water extract from brown propolis on production of IFN- After immunization against canine parvovirus (CPV) and canine coronavirus (CCoV)
Fernandes, Maureen Hoch Vieira; Ferreira, Lilian das Neves; Vargas, Gilberto D'Avila; Fischer, Geferson; Hübner, Silvia de Oliveira.
Ciênc. anim. bras. (Impr.)
; 16(2): 235-242, Abr-Jun. 2015. ilus, graf
Artículo
en Portugués
| VETINDEX | ID: biblio-1473391
The purpose of this study was to evaluate the imunnostimulatory adjuvant capacity of water extract from brown propolis (WEBP) when added to a vaccine against canine parvovirus (CPV) and canine coronavirus (CCoV), regarding the production of IFN-?. Mice were vaccinated with CPV and CCoV (3.0 x 106 TCID50) with or without 400 µg/dose of WEBP. Thirty days after the third dose, splenocytes were cultured to measure the expression levels of IFN-? mRNA in the immunized animals. Increased levels of IFN-? mRNA expression for CCoV were evidenced by RT-PCR, in the splenocytes of mice inoculated with the vaccine containing 400 ?g/dose of WEBP, demonstrating the ability of propolis to stimulate cellular immune responses against the antigens of this virus. In contrast, the levels of IFN-? to CPV were not influenced by the presence of WEBP.
Biblioteca responsable:
BR68.1
Ubicación: BR68.1
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