Coronavirus disease 2019 (COVID-19) pandemic spread rapidly, creating a worrisome scenario worldwide. In hospitalized patients, dysnatremia (hyponatremia and/or hypernatremia) is the most common electrolyte disturbance, reported in 3040% of cases and associated with a poor prognosis. This study aimed to evaluate the association between dysnatremia and mortality in hospitalized patients infected with SARS-COV-2.
Hypernatremia was detected in 83 (76.1%) of the patientswho died, with a cumulative reduction in survival (p < 0.01) and a 2.42-fold increased mortalityrisk (95%CI 1.452.91). In the multivariable analysis, hypernatremia was the main factor associated with increased mortality (HR 1.50; 95%CI 1.231.81). Long length of stay (LOS) (HR 1.54; 95%CI 1.211.78), old age (HR 1.63; 95%CI 1.281.88), and chronic kidney disease (HR 1.77; 95%CI 1.213.30) were also associated with death.