This
research investigated the predictive value of combined
detection of
brain natriuretic peptide (BNP) and
cystatin C (Cys C) in
heart failure after
percutaneous coronary intervention (PCI) in
patients with acute
myocardial infarction (AMI). Sixty-five AMI
patients complicated by
heart failure (HF) after PCI and 79 non-
heart failure (non-HF)
patients were involved in this
research . The levels of Cys C and BNP were measured.
Risk factors for
heart failure in AMI
patients after PCI were analyzed by multivariate
logistic regression analysis .
Efficacy of BNP and Cys C on predicting
heart failure were analyzed by
receiver operating characteristic (ROC) curve. Cys C and BNP levels were significantly higher in the HF group than in the non-HF group. BNP and Cys C levels were the independent influencing factors causing
heart failure within one year after PCI. The area under the predicted curve (
AUC ) of Cys C, BNP, and combined Cys C and BNP were 0.763, 0.829, and 0.893, respectively. The combined
detection of Cys C and BNP was highly valuable in predicting
heart failure in AMI
patients after PCI, which can be regarded as the
serum markers for
diagnosis and
treatment of
heart failure .