ABSTRACT
Laryngeal cancer ranks third among the most common
head and neck neoplasms. The most common histological subtype is
squamous cell carcinoma, and
neuroendocrine tumors are rare. An even rarer entity is a composite
tumor with both these histologies. This
case reports a metastatic combined
carcinoma of
squamous cells and large
neuroendocrine cells, presenting favorable response to
treatment with a total
laryngectomy followed by adjuvant
therapy including chemo-,
radio-, and
immunotherapy.