ABSTRACT
Pyometra is a common
disease in intact
female dogs and can cause glomerulopathy and tubular
injury. This study aimed to evaluate
kidney injury in
female dogs with
pyometra, as well as progression of the
injury during
treatment and the markers of this condition. This study analyzed 20 intact
female dogs with both clinical and sonographic
diagnosis of
pyometra.
Dogs were treated with intravenous fluids and
antibiotics, and an ovariohysterectomy was performed. The following
parameters were assessed at eight separate
time points
blood pressure;
serum creatinine,
phosphorus, and
urea levels;
urinalysis and urinary biochemical
parameters [urinary gamma-glutamyl
transferase (uGGT) and urinary
protein-to-
creatinine ratio (UPCR)];
glomerular filtration rate (GFR); and
urine output. All
dogs showed some degree of
kidney injury at the
time of
pyometra diagnosis. This was
transient in most
animals, resolving with
treatment of the
pyometra. Measurement of uGGT and UPCR identified renal parenchymal
injury, helping to determine the
prognosis of the
animals analyzed in the present study.
RESUMO A
piometra é
afecção frequente em cadelas e pode causar glomerulopatias e
lesões tubulares. O presente estudo objetivou avaliar
injúria renal em cadelas com
piometra, sua progressão ao longo do
tratamento e o uso de marcadores dessa alteração. Participaram 20 cadelas com
diagnóstico clínico e ultrassonográfico de
piometra, submetidas à
fluidoterapia, antibioticoterapia e ovariohisterectomia. Foram avaliados
pressão arterial, concentração sérica de
creatinina,
fósforo e
ureia;
urinálise e
bioquímica urinária (
gama-glutamiltransferase urinária e razão
proteína/
creatinina urinárias),
taxa de filtração glomerular e débito urinário, em oito tempos. Todas as cadelas apresentaram algum grau de
injúria renal no momento do
diagnóstico da
piometra, sendo transitória na maioria dos
animais após o
tratamento. O uso de marcadores de
injúria renal identificou
lesão de
parênquima renal, contribuindo com o
prognóstico dos
animais estudados.