ABSTRACT
Orofacial pain is related to
tissues of the
head,
face,
neck and all the intraoral structures; it is rather debilitating to the
patient and also difficult to treat. There are relatively few studies dedicated to the use of
natural products to alleviate
orofacial pain in preclinical experiment models (performed in experimental
animals which provide support for clinical trials). Main objectives of the present
systematic review summarize the studies on
natural products assessed in
animal models for
orofacial pain seeking to give evidence to
future development of new
pharmaceutical products to manage the
orofacial pain. Our
review includes a thorough search of
literature using the terms of
orofacial pain,
facial pain,
medicinal plants and
natural products. This search was performed using to retrieve English
language articles in
Medline-
PubMed, Scopus and Web of
Science. A total of eighteen studies were included in our
survey for the inclusion criteria. Firstly, this
review identified 210 citations from
electronic search, after removal of duplicates and
screening for relevant titles and abstracts, a total of eighteen articles were selected to the inclusion criteria established. Our findings suggest that
natural products can be a promising or a trump tool for the development of
new drugs to treat
orofacial pain conditions, but the
researchers that deal with experimental preclinical trials of
new drugs (including
natural products or
synthetic drugs) for
orofacial pain conditions urgently need to show translational evidence (with clinical approach) of these compounds.