Evolution of equine influenza viruses (H3N8) during a Brazilian outbreak, 2015
Favaro, Patricia Filippsen; Fernandes, Wilson Roberto; Reischak, Dilmara; Brandão, Paulo Eduardo; Silva, Sheila Oliveira de Souza; Richtzenhain, Leonardo José.
Braz. j. microbiol
; 49(2): 336-346, Apr.-June 2018. tab, graf
Artículo
en Inglés
| LILACS | ID: biblio-889223
Abstract Equine influenza is one of the major respiratory infectious diseases in horses. An equine influenza virus outbreak was identified in vaccinated and unvaccinated horses in a veterinary school hospital in São Paulo, SP, Brazil, in September 2015. The twelve equine influenza viruses isolated belonged to Florida Clade 1. The hemagglutinin and neuraminidase amino acid sequences were compared with the recent isolates from North and South America and the World Organisation for Animal Health recommended Florida Clade 1 vaccine strain. The hemagglutinin amino acid sequences had nine substitutions, compared with the vaccine strain. Two of them were in antigenic site A (A138S and G142R), one in antigenic site E (R62K) and another not in antigenic site (K304E). The four substitutions changed the hydrophobicity of hemagglutinin. Three distinct genetic variants were identified during the outbreak. Eleven variants were found in four quasispecies, which suggests the equine influenza virus evolved during the outbreak. The use of an out of date vaccine strain or updated vaccines without the production of protective antibody titers might be the major contributing factors on virus dissemination during this outbreak.
Asunto(s)
Animales Variación Genética Brotes de Enfermedades Infecciones por Orthomyxoviridae/veterinaria Evolución Molecular Subtipo H3N8 del Virus de la Influenza A/aislamiento & purificación Enfermedades de los Caballos/epidemiología Enfermedades de los Caballos/virología Orthomyxoviridae Proteínas Virales/genética Brasil/epidemiología Análisis de Secuencia de ADN Infecciones por Orthomyxoviridae/epidemiología Infecciones por Orthomyxoviridae/virología Glicoproteínas Hemaglutininas del Virus de la Influenza/genética Sustitución de Aminoácidos Subtipo H3N8 del Virus de la Influenza A/clasificación Subtipo H3N8 del Virus de la Influenza A/genética Genotipo Caballos Hospitales Veterinarios Neuraminidasa/genética
Biblioteca responsable:
BR1.1
powered by iAHx-2.18-89
Biblioteca Virtual en Salud