Electroacupuncture ameliorate learning and memory by improving N -acetylaspartate and glutamate metabolism in APP/PS1 mice

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Lin, Ruhui; Li, Long; Zhang, Yingzheng; Huang, Sheng; Chen, Shangjie; Shi, Jiao; Zhuo, Peiyuan; Jin, Hao; Li, Zuanfang; Liu, Weilin; Wang, Zhifu; Chen, Lidian; Tao, Jing.

Biol. Res ; 51: 21, 2018. graf

Artículo en Inglés | LILACS | ID: biblio-950905

OBJECTIVE:

To explore the precise mechanism of electroacupuncture (EA) to delay cognitive impairment in Alzheimer disease. Methods N -Acetylaspartate (NAA), glutamate (Glu) and myoinositol (mI) metabolism were measured by magnetic resonance spectroscopy, learning and memory of APP/PS1 mouse was evaluated by the Morris water maze test and the step-down avoidance test, neuron survival number and neuronal structure in the hippocampus were observed by Nissl staining, and BDNF and phosphorylated TrkB detected by Western blot.

EA at DU20 acupuncture significantly improve learning and memory in behavioral tests, up-regulate NAA, Glu and mI metabolism, increase the surviving neurons in hippocampus, and promote the expression of BDNF and TrkB in the APP/PS1 transgenic mice.

These findings suggested that EA is a potential therapeutic for ameliorate cognitive dysfunction, and it might be due to EA could improve NAA and Glu metabolism by upregulation of BDNF in APP/PS1 mice.

Animales Masculino Ratones Electroacupuntura/métodos Ácido Aspártico/análogos & derivados Ácido Glutámico/metabolismo Hipocampo/química Aprendizaje/fisiología Memoria/fisiología Proteínas Tirosina Quinasas/análisis Imagen por Resonancia Magnética Glicoproteínas de Membrana/análisis Ratones Transgénicos Espectroscopía de Resonancia Magnética Distribución Aleatoria Western Blotting Ácido Aspártico/metabolismo Aprendizaje por Laberinto Factor Neurotrófico Derivado del Encéfalo Modelos Animales Prueba de Esfuerzo Hipocampo/diagnóstico por imagen Inositol/análisis

Biblioteca responsable: CL1.1