The use of the software JST-XRD for identification of crystalline phases in pharmaceutical raw materials and tablets / Uso do software JST-XRD para identifcação de fases cristalinas em insumos farmacêuticos e medicamentos
Tanaka, Julia Sawaki; Salvi, Simone de; Antonio, Selma Gutierrez; Paiva-Santos, Carlos de Oliveira.
Rev. ciênc. farm. básica apl
; 37(1): 2-8, 2016. ilus, tab, graf
Artículo
en Inglés
| LILACS | ID: biblio-963611
Study of polymorphism is of great importance for the pharmaceutical industry once polymorphs may display diï¬erent physicochemical properties, which, in turn, may result in stability diï¬erences that can bring problems for the manufacturing stages and the quality of fnal products. Although research on organic polymorphs has greatly increased in the last decades, it still does not cover all needs for the pharmaceutical market. Techniques such as spectroscopy in the infrared region, nuclear magnetic resonance, thermal analysis, X-ray diï¬raction, etc., can be used to identify polymorphism. The polymorphism is a property of the crystalline solid state, and can be evaluated by X-ray diï¬raction once each polymorph exhibits one specifc X-ray diï¬raction pattern. The JST-XRD program is a tool designed to help the identifcation of crystalline phases (including polymorphs) present in pharmaceutical ingredients and tablets by using X-ray diï¬raction data obtained from scientifc articles and patents. This paper presents new implementations for the JST-XRD and describes its use in the analysis of active pharmaceutical ingredient and marketed tablets of norï¬oxacin, mebendazole and atorvastatin calcium. By the means of comparison, JSTXRD allowed identifying the crystalline phases in the diï¬raction patterns of the analyzed drugs, showing the program suitability for polymorphism research, pre-formulation and quality control in pharmaceutical industries. JST-XRD can also be used for educational purposes in undergraduate and graduate programs in order to show the potentiality of X-ray powder diï¬raction in polymorphism analysis.(AU)
Biblioteca responsable:
BR33.1
Texto completo
Documentos relacionados