Performance of rapid tests compared to conventional tests used for HIV diagnosis / Desempenho dos testes rápidos em relação aos testes convencionais utilizados no diagnóstico de HIV
Castejon, Márcia Jorge; Yamashiro, Rosemeire; Oliveira, Carmem Aparecida F; Brigido, Luis Fernando M; Generoso, Igor P; Veras, Maria Amélia S. M; Kerr, Ligia Regina F. S.
J. Bras. Patol. Med. Lab. (Online)
; 54(6): 364-371, Nov.-Dec. 2018. tab
Artículo
en Inglés
| LILACS, SESSP-IALPROD, SES-SP | ID: biblio-975862
ABSTRACT
Introduction:
Early diagnosis is an important tool for strategies to fight human immunodeficiency virus (HIV) infection.Objective:
The main objective of this study is to evaluate the comparability of the results of rapid tests (RT) used for the HIV diagnosis in relation to conventional molecular and serological tests in blood samples from a population of men who have sex with men (MSM), from 12 Brazilian capitals. Material andmethods:
591 HIV-1 reactive test samples from 4176 MSM participants were submitted to Instituto Adolfo Lutz (IAL) for evaluation by conventional laboratory tests. From these samples with at least one RT reagent, 522 samples were analyzed, and in 493 (94.4%) the HIV positivity was confirmed, with 33% HIV-1 viral load above 5,000 copies/mL and 67% by the serological tests. A total of 336 (10%) samples with a non-reactive RT result were evaluated by standard serology, four (1.2%) tested positive for HIV. Results andconclusion:
The results showed a high percentage of samples with confirmed HIV positivity in the conventional laboratory tests, as well as some non-reactive results that were confirmed positive, indicating some limitations of the RT single-step method. Therefore, the serological tests had a fundamental role in clarifying the diagnosis.
Biblioteca responsable:
BR91.2
Ubicación: BR91.2; P
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