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Alta frecuencia de DQ8 en la población celiaca de la provincia del Chaco, Argentina. / [High frequency of DQ8 in the celiac population of Chaco province, Argentina].

Motta Patricía Maria F; López María A; Marinic Karina; Picón Santiago O; Stafuza Mariana G; Habegger de Sorrentino Alicia.
Acta Gastroenterol. Latinoam. ; 44(1): 16-21, 2014 Mar.
Artículo en Español | BINACIS | ID: bin-133705

BACKGROUND:

There is a strong association between celiac disease (CD) and certain genes of the major histocompatibility complex (HLA). The CD specifically related alleles are those coding for HLA-DQ2 heterodimer and to a lesser degree for HLA-DQ8. OBJECTVE. The aim of this study was to evaluate the frequency of HLA-DQB1* and HLA-DRB1* alleles, haplotypes, and genotypes in patients diagnosed with CD and in control population of Chaco, in order to establish its distribution and compare it with that observed in other populations.

METHODS:

A total of 139 samples from patients diagnosed with CD and 119 healthy controls were typed for HLA-DQ and HLA-DR, using PCR and reverse hybridization (INNO-LiPA or Dynal).

RESULTS:

Comparing patients with CD vs. controls, the DQBI*0201 (P = 0.0002), DQBJ*0202 (P = 0.0046), DQBI*0302 (P = 0. 0006), DRBl *03 (P = 0.0002), DRBl *04 (P = 0.0199) and DRB1 *07 (P = 0.0062) were significantly increased, while a decrease was observed in HLA-DQB1*0301 (P = 0.0006), HLA-DQBI*0303 (P = 0.0070), DQBI*0501 (P = 0.0023), DQB1*0604 (P = 0.0140) DRB1*01 (P = 0.0023), DRB1*08 (P = 0.0165), DRB1*09 (P = 0.0362) and DRB1*16 (P = 0.0228). Within DQB1* genotypes associated with EC, 65.4

Asunto(s)

Enfermedad Celíaca/genética Predisposición Genética a la Enfermedad/genética Antígenos HLA-DQ/genética Cadenas HLA-DRB1/genética Adolescente Adulto Anciano Argentina Estudios de Casos y Controles Femenino Frecuencia de los Genes Genotipo Haplotipos Humanos Masculino Persona de Mediana Edad Adulto Joven
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