Induction of IgA and sustained deficiency of cell proliferative response in chronic hepatitis C
Amador-Cañizares, Yalena; Alvarez-Lajonchere, Liz; Guerra, Ivis; Rodríguez-Alonso, Ingrid; Martínez-Donato, Gillian; Triana, Julián; González-Horta, Eddy E; Pérez, Angel; Dueñas-Carrera, Santiago.
World J Gastroenterol
; 14(44)Nov 28, 2008.
Artículo
en Inglés
| CUMED | ID: cum-39739
AIM:
In the present study, antibody and peripheral blood mononuclear cells (PBMC) proliferative responses against hepatitis C virus (HCV) antigens were evaluated in HCV chronically infected patients.METHODS:
Paired serum and PBMC samples were taken six months apart from 34 individuals, either treated or not, and tested by enzyme-linked immunosorbent assay (ELISA) and carboxyfluorescein succinimidyl ester staining.RESULTS:
Over 70% of the patients showed specific IgG and IgM against capsid, E1 and NS3, while HVR-1 was recognized by half of the patients. An increase in the levels of the anti-capsid IgM (P = 0.027) and IgG (P = 0.0006) was observed in six-month samples, compared to baseline. Similarly, a significantly higher percent of patients had detectable IgA reactivity to capsid (P = 0.017) and NS3 (P = 0.005) after six months, compared to baseline. Particularly, IgA against structural antigens positively correlated with hepatic damage (P = 0.036). IgG subclasses evaluation against capsid and NS3 revealed a positive recognition mediated by IgG1 in more than 80% of the individuals. On the contrary, less than 30% of the patients showed a positive proliferative response either of CD4+ or CD8+ T cells, being the capsid poorly recognized.CONCLUSION:
These results confirm that while the cellular immune response is narrow and weak, a broad and vigorous humoral response occurs in HCV chronic infection. The observed correlation between IgA and hepatic damage may have diagnostic significance, although it warrants further confirmation(AU)
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