Effects of policosanol on gastroprotective action of D-002

Carbajal Quintana, Daisy; Molina Cuevas, Vivian; Ravelo Calzado, Yazmin; Zamora Rodríguez, Zullyt; Mas Ferreiro, Rosa

Introduction:

policosanol, a mixture of higher aliphatic alcohols purified from sugar cane wax, is used to treat hypercholesterolemia. D-002 (Abexol), a mixture of higher aliphatic alcohols from beeswax, is an antioxidant supplement with gastroprotective effects. Then, concomitant intake of D-002 and policosanol may occur in routine practice, so potential pharmacological interactions between them should be researched on.

Objective:

to find out the influence of policosanol on the gastroprotective effect of D-002 on the ethanol-induced gastric ulcer model.

Methods:

rats were randomized into eight groups one treated with the vehicle (control), two with D-002 (25 and 200 mg/kg), two with policosanol (25 and 200 mg/kg), two with the same doses of D-002 + policosanol and other with sucralfate (100 mg/kg). Treatments were given as single oral doses. One hour after treatment, rats received 60% ethanol orally and one hour later they were killed and their stomachs exposed. Effects on ulcer indexes (UI) were assessed.

Results:

acute oral administration of D-002 (25 and 200 mg/kg) significantly reduced the ulcer indexes by 40 percent and 68 percent, respectively, as compared to the control group, and policosanol by 26 percent and 47 percent, respectively. The concomitant administration of the same doses of D-002 and policosanol significantly decreased ulcer indexes by 64 percent (both given at 25 mg/kg) and by 92 percent (both given at 200 mg/kg) as compared to the respective monotherapies. Sucralfate (100 mg/kg) significantly reduced (@ 99 percent) ulcer indexes compared to the control group.

Conclusions:

the concomitant oral administration of policosanol with D-00 2 gives greater gastroprotection than D-002 monotherapy, so both products can be taken together(AU)

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