The case reports of 2 young adults of both sexes are described, assisted in the Internal Medicine Service of Dr Juan Bruno Zayas Alfonso TeachingGeneral Hospital in Santiago de Cuba with similar clinical patterns (marked weakness, easy fatigue, heart racing, increase of volume of lower limbs and bony pains, among others). The results of the physical and complementary exams confirmed that it was an association of ulcerative colitis, autoimmune hemolytic state and vitiligo. That is why it is necessary to carry out a deep study in each patient that presents any of these clinical disorders(AU)