The
analgesic activity was tested by Eddy's hot plate
method in albino
mice using combination of
Pentazocine [1 mg/kg] with
Phenytoin [10.20 mg/kg] and
Pentazocine [1 mg/kg] with
Ketorolac [10.20 mg/kg] was given by intra-peritoneal
administration, The results showed a significant increase in
reaction time [
analgesia] in albino
mice and hence the present study indicates that combination of
Phenytoin and
Ketorolac with
Pentazocine has significant prolonged
analgesic effect as compared with
analgesic effect produced by
Pentazocine alone