To compare
hypoglycemic effect of
Pioglitazone and
Metformin in
type 2 Diabetes Mellitus. Quasi experimental study. Department of
Medicine, Military Hospital Rawalpindi Cantt from 11-01-2007 to 12-08-2007. Sixty
patients of
type 2 diabetes mellitus from outdoor department were selected. On arrival at OPD each
patient was examined thoroughly.
Therapeutic option was allocated to the
patients simply by using a table of random numbers and dividing them in two equal groups. Informed written consent was obtained. Each
patient was followed on monthly subsequent visits [six in total] and his HbA1c,
fasting and random
blood glucose were recorded carefully. All the data thus obtained was processed and analyzed using SPSS version 10.0. Mean and SD were calculated for age, BMI,
fasting blood glucose, random
blood glucose and HbA1c levels. Mean drop of all three
parameters were compared among two groups. At the end of six months, it was revealed that
fasting and random [2 hours postprandial]
blood glucose dropped more in
Pioglitazone group; P=0.000 and 0.02 respectively. While almost comparable effect was observed in HbA1c [P=0.2].
Pioglitazone has significantly better
hypoglycemic effect than
Metformin in
type 2 diabetes mellitus at the end of six months
therapy