To find out the frequency of
Helicobacter pylori in
patients presenting with perforated
duodenal ulcer. This
observational study was conducted at Lady
Reading Hospital Peshawar from July 2004 to January 2005 on 100
patients with confirmed
diagnosis of perforated
duodenal ulcer fulfilling the inclusion criteria. A semi-structured
Questionnaire was designed for the study. Out of a total of 200
patients operated for perforated
duodenal ulcer 100
patients were fulfilling study criteria. Among these100
patients 80 were
males and 20 were
females. The participants were ranging from 18 to 72 years in age with mean age of 47.02 +/- 13.42 years.
Helicobacter pylori were found in 80[80%]
patients on histopathology and 65 [65%]
patients on rapid
urease test
Infection rates were maximum in the
elderly and those
belonging to poor socioeconomic class. All infected
patients were treated with triple regimen eradication
therapy comprising of
clarithromycin,
Proton Pump Inhibitor [PPI], and
amoxicillin for 14 days. The
patients were not followed to confirm eradication status. The spectrum of H. Pylori
infection is very high in
patients with
duodenal ulcer perforation. An early and appropriate H. Pylori eradication
therapy may prevent
duodenal ulcer perforation