To compare the
therapeutic efficacy of
Intravenous immune globulin [
IVIG ] with
Plasma exchange [plasmaphoresis] in
patients of
Acute Inflammatory Demyelinating Polyneuropathy i.e.
Guillain-Barre syndrome [GBS].
Randomized Controlled Trial [RCT]. The study was of 12 months duration conducted at Department of
Medicine ,
Neurology Unit of
Military Hospital Rawalpindi from Jun 2008 to Jun 2009. 60
Patients of GBS were randomly assigned to two
treatment groups. Group A received
Intravenous immune globulin [
IVIG ] and Group B
Plasma Exchange .
Patient 's
functional status according to
London scale grade was assessed at the
time of admission and at 02 and 04 weeks after giving
treatment . Improvement in mean
London scale Grades in each group was calculated at different weeks from baseline and then both groups were compared to each other. In each group there was significant improvement [P-value< 0.001] from baseline-2weeks and baseline-4 weeks. But when compared to each other both the groups had comparable improvement [p-value> 0.05]. Both
IVIG and
Plasma Exchange have equal
therapeutic efficacy in the
treatment of
patients of GBS