Serum vitamin D and parathormone [PTH] concentrations as predictors of the development and severity of diabetic retinopathy
Rania Naguib Abdel Mouteleb, Abdel Reheem; Maaly Abdel Halim Mohamed, Abdel Fattah.
AJM-Alexandria Journal of Medicine. 2013; 49 (2): 119-123
en Inglés
| IMEMR | ID: emr-145371
Vitamin D is suggested to be an inhibitor of angiogenesis. The degree of severity of diabetic retinopathy [DR] may be related to serum vitamin D concentration. Investigating vitamin D and parathormone [PTH] concentrations as predictors of the development and severity of diabetic retinopathy. Two hundred diabetic patients presenting with suspected diabetic retinopathy were investigated, levels of vitamin D [25[OH] D3 and Calcitriol] and PTH were measured. Diabetic retinopathy was assessed using 7-field stereoscopic Fundus photography. Mean serum concentration of 1, 25 dihydroxy vitamin D 3 [1, 25[OH] 2 D3] was significantly lower in diabetic subjects with retinopathy than in diabetic subjects with no retinopathy and there is a significant negative correlation between the mean level of 1, 25[OH] 2 D3 and the degree of severity of retinopathy. Level of PTH was significantly higher in severe NPDR and PDR compared to patients with no retinopathy. Low levels of vitamin D might be a risk marker of development or progression of diabetic retinopathy. It might be advisable that detailed ophthalmologic examination is needed for diabetics whose serum 1, 25[OH] 2D3 concentrations gradually decreased. The measurement of serum 1, 25[OH] 2 D3 concentrations could become a useful biochemical means to predict the severity of DR in patients with diabetes mellitus
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