To determine the
effectiveness of vaginal
Misoprostol for the
second trimester termination of
pregnancy. Prospective randomized trial. This study was carried out in the Unit of Post Graduate Medical Institution Peshawar I aJv
Reading Hospital Peshawar from 1[st] January till 31[st] December 2006. A total of 100
patients were included in this study.
Misoprostol 400 microgram, was dministered intra-vaginally and repeated after every 4 hours up to a maximum of five doses or until the termination of
pregnancy, which ever was earlier. The exclusion criteria were as
allergy to
prostaglandin, a previous classic
caesarean section or
Hysterectomy, active
vaginal bleeding, severe
asthma and
epilepsy. Period of
gestation ranged from 12 to 20 weeks, Indications for 2' trimester termination of
pregnancy .ere chromosomal or structural
fetal anomalies [
anencephaly] whether dead or alive,
missed abortion intrauterine
fetal death. Success rate at 48 hours was 90%. The median induction to termination interval was 16 hours. Few Aomen suffered gastrointestinal side effects such as
nausea [6%],
vomiting [3%] and
diarrhea [1%]. 400 Microgram of Vaginal
Misoprostol is highly effective way of
cervical ripening and termination of
second trimester pregnancy