To evaluate the
antidiabetic effects of the
alcoholic extract of leaves and
stem of I. auamoclit employing a short term study. A short tem study was carried as a preliminary investigation to evaluate the
antidiabetic effect of the
alcoholic extract of leaves and
stem of I. quamoclit and its normoglycemic and
antihyperglycemic activity in
streptozotocin [STZ[-
nicotinamide induced non
insulin-dependent diabetes mellitus rats using
Glucose Tolerance Test t[GTT]. Graded doses [250 and 500 mg/kg] of the
alcoholic root extract suspended in
gum acacia were administered to normal and experimental diabetic
rats. A significant fall in the
blood glucose level of extract-treated
animals was seen after 1 hour, indicating its
hypoglycemic activity. Continuous
blood glucose lowering activity was observed up to 4 hours of
administration in normoglycemic and diabetic
rats. The results were compared with those following the
administration of standard oral
hypoglycemic agent,
glibenclamide.
Administration of the
alcoholic extract caused statistically significant decrease in the
blood glucose levels of normal and diabetic
rats as compared to the normal control and diabetic
control groups respectively. Longer duration studies of
Ipomoea quamoclit on chronic models may contribute toward the development of a potent
antidiabetic drug