The aim of the present
work was to prepare a
nasal spray of
bisoprolol fumarate [BF]. The
Pharmacokinetics and relative
bioavailability of the BF nasal formulation were evaluated in
Wistar rats. The BF
nasal spray after
administration exhibited very fast
absorption and higher
plasma drug concentration. The maximum
plasma concentration [C[max]] and the
time to reach it [T[max]] were 409.5ng/ml and 3.6 min for the BF
nasal spray, 39.4ng/ml and 26.7min for the
drug solution, respectively. The
bioavailability of the BF
nasal spray was greater than 1500.0%. Meantime, the effect of the BF
nasal spray on nasal mucociliary
movement was also studied with a
toad palate model. The BF nasal preparation showed
minor ciliotoxicity, but the adverse effect was temporary and reversible