protective activity of serum and fractionated serum from rats against babesia divergens
Najla, Ben Musa; Hamdy A., Dawoud.
Journal of the Egyptian Society of Parasitology. 2004; 34 (2): 407-22
en Inglés
| IMEMR | ID: emr-66745
The rat adapted strain of bovine babesia, B. divergens, was used as a model to investigate the mechanisms of immunity to this parasite. The effect of the humoral factors in the acquired immunity to B. divergens was investigated in splenectomized rats. Antibodies to B. Divergens were detected by indirect fluorescent antibody [IFA] test in sera collected during infection and at different times after recovery. The protective activity of the same serum was tested in vivo by passive transfer and compared with the antibody levels as measured by IFA test. The role of antibody in protection was confirmed after fractionating IgM and IgG from immune and hyperimmune sera. The protective activity of sera collected immediately after recovery was mainly due to IgM antibodies. The protective activity of sera collected at 3-4 days after recovery and of hyperimmune sera was mainly due to IgG antibodies. In hyperimmune serum, IgM antibodies were partially protective
Biblioteca responsable:
EMRO
Documentos relacionados