Humans are exposed to
Cadmium through
environmental pollution,
industries, food contamination and
cigarette smoking and is a sort of cumulative
poison especially in
kidneys, where it is nephrotoxic.
Calcium has been reported to modify
cadmium binding to its proximal
brush border membrane receptors. In this study,
adult spraguedawly
rats were fed identical
diet, treated with
cadmium 1.0 mg, 0.5mg and O. lmg/Kg
body weight twice a day for tweleve weeks. Other groups were treated similarly with
cadmium and
calcium carbonate orally. There was severe renal parenchymal damage in
cadmium treated groups than the groups which received both
cadmium and
calcium carbonate orally