Radioquimioterapia en el carcinoma localmente avanzado de cérvix / Radiochemotherapy in locally advanced carcinomas of the cervix
Fernández-Fernández, MC; Fernández-Fernández, JC; Jiménez-Torres, MJ; Vargas, JA.
Clín. investig. ginecol. obstet. (Ed. impr.)
; 33(1): 2-6, ene.-feb. 2006. ilus, tab
Artículo
en Es
| IBECS (España) | ID: ibc-043583
Introduction:
The aim of this study was to evaluate the role of concurrent cisplatin (CDDP) plus standard radiotherapy (RT) in the treatment of locally advanced cervical cancer.Methods:
Between 2000 and 2003, 68 patients with histologically confirmed locally advanced carcinoma of the cervix received radiotherapy (external-beam radiotherapy and brachytherapy) plus weekly cisplatin chemotherapy (40 mg/m2).Results:
All patients were available for analysis. The mean follow-up period was 40 months. Fifty-six patients had squamous cancer and 12 had adenocarcinoma. Tumoral stages were bulky stage IB in 16 patients, stage IIB in 12, stage IIIA in 20 and stage IIIB in 20. The most frequent type of toxicity was gastrointestinal in 24 patients. Of 52 patients who underwent total hysterectomy with bilateral annexectomy, no tumor was found in the surgical specimen in 57%. The 3-year survival rate (Kaplan-Meier) was 75%.Conclusion:
This study shows that local control and survival with concurrent radical RT plus weekly CDDP chemotherapy at a weekly dose 40 mg/m2 has beneficial effects in the treatment of these tumors (AU)
Biblioteca responsable:
ES1.1
Ubicación: ES1.1 - BNCS
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