Glomerulosclerosis nodular diabética sin diabetes mellitus conocida previamente / Nodular diabetic glomerulosclerosis without previously known diabetes mellitus
Nephropathy is one of the chronic complications of diabetes mellitus associated with an increase in morbidity and mortality in the affected population. This complication can be detected after several years of disease evolution in type 1 diabetes mellitus and soon after diagnosis in diabetes type 2 or even at its onset. The development of nephropathy without previously known diabetes mellitus is highly infrequent. We describe two patients with diabetic nephropathy and no previous history of diabetes mellitus. One of the patients was subsequently diagnosed with carbohydrate intolerance. In the other patient, study of carbohydrate metabolism was normal. We review the literature on the topic and the genetic and environmental mechanisms involved in the development of this disease. The importance of including diabetic nephropathy in the differential diagnosis of nodular glomerulosclerosis, even in patients without previously known diabetes mellitus, is also discussed