Determinación del fragmento N-terminal del propéptido natriurético cerebral (NTproBNP) en pacientes de edad avanzada con disnea aguda: valor diagnóstico y pronóstico / Measurement of NT-proBNP in elderly patients with acute dyspnea: diagnostic and pronostic value
En el estudio se incluyó a 79 pacientes con disnea aguda, con una edad media (desviación estándar) de 77,56 (8,71) años. Se estableció el diagnóstico de IC en el 67% de ellos a partir de criterios clínicos y ecocardiográficos. Se realizó un seguimiento prospectivo de los pacientes a los 18 meses.
Resultados:
Los valores de NTproBNP se encontraron más elevados en los pacien tes con IC (6.833,54 pg/ml) que en aquéllos con disnea atribuible a otra causa (1.801,99 pg/ml) (p < 0,0001). En los que presentaron valores de NTproBNP superiores a 730 pg/ml la frecuencia de reingreso a los 18 meses de seguimiento fue mayor.
Conclusiones:
El NTproBNP es un parámetro útil para diferenciar y clasificar desde el punto de vista pronóstico a pacientesancianos con disnea asociada a IC
Background and
objective:
The aim of our study was to establish weather N-terminal fragment of brain-type natriuretic peptide (NT-proBNP) is useful in the differential diagnosis of dyspnea in elderly patients, and whether its determination has a prognostic value in heart failure (HF). Patients and
method:
79 patients admitted with acute dyspnea at the emergency department were included in our study. The mean age (standard deviation) was 77.56 (8.71) years. 67% had a diagnosis of HF based on clinical and echocardiagraphic criteria. A follow-up of 18 months was performed after discharge.
Results:
Higher levels of NT-proBNP were found in patients with HF (6,833.54 pg/ml) than in patients with other causes of dyspnea (1,801.99 pg/ml) (p 730 pg/ml was related to higher rates of readmission due to HF over the next 18 months.
Conclusions:
NT-proBNP is a useful biomarker in the differential diagnosis of dyspnea in the elderly population. Its determination has a prognostic roll, stratifying the risk of readmission in HF patients