During the last 50 years several papers have been put forward to explain induce immunological changes in relationship with exclusive or determinate oral diseases. The objective of this presentation is to make a rewire about what is published at the moment about of innated and adaptive immune response, in relationship with oral mucosa, and an overwide of the role (s) of immune cells, cytoquines, receptors, grow factors, and other secretory products associated with health, inflammation, chronic stress, Immune dysregulation aging, inmuno tolerance and inmunosenescence (AU)