Expression of the FUT2 gene and CD44 marker in patients with oral lesions
Ensinck, Mar¨ªa Alejandra; Valles, Melissa; Lebensohn, Natalia; Cotorruelo, Carlos; Biondi, Claudia.
Inmunología (1987)
; 32(4): 123-128, oct.-dic. 2013. ilus, tab
Artículo
en Inglés
| IBECS (España) | ID: ibc-117490
The aim of this work was to investigate the FUT 2 gene, the secretor status and the expression of CD44 protein in epithelial cells obtain from saliva samples from patients with oral lesions (benign, pre-cancerous and cancerous lesions, n = 94). We analyzed polymorphisms of the FUT2 gene by allele specific oligonucleotide¨Cpolymerase chain reaction. The FUT2 gene encodes the ¦Á(1,2) fucosyltransferase (Se enzyme) that regulates the expression of ABH antigens in secretions. Generally speaking, being a non-secretor has several disadvantages with regard to metabolism and immune function. In this study, we found that oral pre-cancerous and cancerous lesions were increased among individuals with non-secretor status and nonsense mutation 428G¡úA. Fifty-one percent of the patients with oral pre-malignant and malignant lesions were non-secretors, in contrast with the healthy population (OR = 3.44). We observed a marginal association between secretor status and these lesions. Our study suggests that the lack of wild type FUT2 gene and a non-secretor status appear to be an associated risk marker for the development of oral cancer in patients with oral lesions (AU)
Biblioteca responsable:
ES1.1
Ubicación: BNCS
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