In recent years there has been an increase in the publications in the scientific literature on the toxic reactions, physical complications and deaths associated with recreationsdrug use, parallel to increase in the prevalence of this drugconsumption. In addition to the adverse reactions that can be observed associated with acute intoxication, use of these substances may cause cardiovascular complications, cerebrovascular accidents, convulsions, hyponatremia leading to cerebral aedema, as well as important hepatotoxic effects. However, one of the most severe complications that may develop is a hyperthermic syndrome that may evolve to diseminated intravascular coagulation, rhabdomyolysis, and acute renal failure. The treatment of acute intoxication, in light of the absence of a specific antidote the management is primarily symptomatic and supportive (AU)