Clinical guideline SEOM: hereditary colorectal cancer

Guillén-Ponce, C; Serrano, R; Sánchez-Heras, AB; Teulé, A; Chirivella, I; Martín, T; Martínez, E; Morales, R; Robles, L

Genetic mutations have been identified as the cause of inherited cancer risk in some colon cancer; these mutations are estimated to account for only 5-6 % of colorectal cancer (CRC) cases overall. Up to 25-30 % of patients have a family history of CRC that suggests a hereditary component, common exposures among family members, or a combination of both. Cancers in people with a hereditary predisposition typically occur at an earlier age than in sporadic cases. A predisposition to CRC may include a predisposition to other cancers, such as endometrial cancer. We describe genetics, current diagnosis and management of CRC hereditary syndromes pointing to a multidisciplinary approach to achieve the best results in patients and family outcomes (AU)

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Clinical guideline SEOM: hereditary colorectal cancer

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