BACKGROUND: This study aimed to
review translational studies focusing on
third molar removal surgeries through a systematic analytical approach. MATERIAL AND
METHODS: A PROSPERO-registered
systematic review (CRD42017060455) was conducted following the PRISMA statement to summarize current
knowledge on
gene expression in
third molar surgeries. A search was performed in
PubMed 's
Medline and Scopus databases, without date or
language restrictions, using the logical expression {[(
Third molar ) OR (preemptive) OR (
cyclooxygenase inhibitors ) OR (acute
inflammation ) AND (
gene expression )]}.
RESULTS: All studies included in the
analysis evaluated
gene expression in a
third molar extraction model, using the preemptive
analgesia methodology in seven investigations. The sample analyzed was obtained from gingival
tissue biopsy (n=4),
blood (n=1),
transudate (n=1) and gingival
tissue biopsy /
transudate (n=1). There were differences with
respect to evaluated
genes ,
drug protocol, sample studied, and
method for evaluating
gene expression .
CONCLUSIONS: Third molar surgeries were found to be associated with different COX-related
gene expression patterns. Although inflammatory events following the
surgical procedure are associated with COX
isoforms , data from preemptive
analgesia studies are scarce, especially from studies correlating
gene expression and clinical
parameters . In the
future , from a clinical perspective, identifying the molecular targets of a
drug based on individual
gene expression may be helpful to delineate specific
third molar ,
surgery -related, preemptive
analgesia protocols