Inhaled corticosteroids may have a protective effect against coronavirus infection

Armentia, Alicia; Fernández Cortés, Sara; Moro Simón, Angela; Martín-Armentia, Blanca; Martín-Armentia, Sara; Ramos Pollo, Daniel; Navarro Cañadas, Juan Claudio; Visa Caño, Javier; Sanz Rubiales, Álvaro; Rodriguez Fra, Joaquín; García Vaquero, Sara; Cano Pazos, Marta; Galán de la Calle, Jesús; Raul Lowell, Edgardo; Crespo Soto, Cristina; Sánchez Toledano, Carmen; Sacristán Salgado, Aurora

BACKGROUND:

Spain has been severely affected by the COVID-19 epidemic, with 195,944 persons infected and 20,453 deaths at the time of writing. Older people with respiratory or cardiac conditions are most at risk.

OBJECTIVE:

The aim was to compare respiratory symptoms in nursing home residents and patients with uncontrolled asthma, who are considered vulnerable to COVID-19.

METHODS:

We studied 134 nursing home residents and 139 patients with uncontrolled asthma, groups vulnerable to COVID-19. Demographic characteristics, clinical manifestations, out-comes, key laboratory results, and radiological images were collected from medical records. COVID-19 infection was detected by polymerase chain reaction (PCR).

RESULTS:

Thirteen (9.3%) patients with uncontrolled asthma, all receiving inhaled corticoste-roids were infected by COVID-19. Eighty (60%) nursing home residents were infected; only 28, all of whom had received inhaled corticosteroids, had a good prognosis

CONCLUSIONS:

Early treatment with inhaled corticosteroids may be helpful in COVID-19 infection. Persons with an allergy might have some protective mechanisms against coronavirus

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