Resveratrol inhibits TGF-B1-induced EMT in gastric cancer cells through Hippo-YAP signaling pathway
Deng, Li; Zou, Jun; Su, Yongfeng; Wang, Meijian; Zhao, Lianwu.
Clin. transl. oncol. (Print)
; 24(11): 2210-2221, noviembre 2022.
Artículo
en Inglés
| IBECS (España) | ID: ibc-210149
To investigate the effects of resveratrol (RSVL) on epithelial-mesenchymal transition (EMT) and biological behaviors of gastric cancer cells.MethodsSGC-7901 cells were treated with RSVL, followed by TGF-β1 treatment for induction of EMT. Cell proliferation was tested by MTT assay, migration and invasion by Transwell and scratch assays, and Hippo-YAP signaling pathway activation by immunofluorescence. The RNA and protein expressions of E-cadherin, Vimentin, N-cadherin, and Snail were detected by qPCR and Western blot. A tumor model was constructed to examine the effect of RSVL on gastric tumor growth.ResultsRSVL inhibited the migration, invasion, and growth of gastric cancer cells in concentration- and time-dependent manners. RSVL inhibited TGF-β1-induced EMT of gastric cancer cells, which might relate to inactivation of the Hippo-YAP pathway. In the mouse tumor model, RSVL inhibited the EMT process by suppressing the Hippo-YAP pathway.ConclusionRSVL inhibited EMT of gastric cancer cells probably by weakening the Hippo-YAP signaling pathway. (AU)
Biblioteca responsable:
ES1.1
Ubicación: ES15.1 - BNCS
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