205 patients were included in the study, 103 females (50.2%) with a median age of 54.8-years (IQR 41.2-65.2). 104 were enrolled to the control group and 101 to the intervention group. Patients receiving premedication presented a higher rate of adequate (74.3% vs 45.2; difference 95% CI 16,3-41,9%, p<0.001) and excellent gastric visibility (23.8% vs 7.7%; difference 95% CI 6,3-25,8%, p=0.002). Propofoldose was similar, although the median proceduretime was lower in the group of no intervention [5 (IQR 4-7) vs 6 minutes (IQR 5-7); p=0.03]. Procedure related adverse events were similar, except that patient without premedication experienced more nausea episodes. Major and minor endoscopic findings and the satisfactionquestionnaire showed no differences between both groups.